Abstract

Pyrimidine compounds are of potential biological interest .Introduction of various functional groups in different positions on the pyrimidine ring leads to a large number of derivatives with significant drug likeess. The presence of biological activity was confirmed using molecular docking studies. In this study, synthesized pyrimidine derivatives were docked with the Thyroid hormone receptor β using Schrödinger Software suite2009. The Thyroid hormone receptor β is responsible for Hyperthyroidism. These pyrimidine derivatives showed better efficiency in binding to the receptor, which was evaluated from the glide scores. Results proved that the synthesized pyrimidine derivatives could act as potential leads when the electron withdrawing substituent is present in 4th position of the pyrimidine moieties

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